Nathan Drake will cameo in one final adventure, but it's his brother Sam who will take the lead in Uncharted 4: A Thief's End's standalone story spin-off. The all-new adventure – which will apparently be announced at PSX 2016 next week – will allegedly launch early next year, and will see Drake "handing over the adventuring reins" to his sibling. That's all according to a report on Jaffameister, but it tallies with previous things that we've heard.
Apparently the story will be longer than the critically acclaimed The Last of Us: Left Behind; given that was a good few hours, this will probably take the guise of a mini-campaign. Naughty Dog's clearly been busy these past few months, because it's also just announced Uncharted 4: Survival – a co-operative add-on for the main game. Drake may be hanging up his half-tuck, but it seems like there's plenty of life in this franchise yet.