Do you need a Chapter 16 walkthrough for Resident Evil 4? This is the fifteenth of 16 Chapters in the game, which form the Main Story. As part of our Resident Evil 4 Remake guide, we're going to share our in-depth Chapter 16 walkthrough. It will cover every enemy encounter, puzzle solutions, highlight Collectibles, mention Blue Request Notes, and touch on any other points of interest. The walkthrough is broken down into the main objectives the game tells you to complete.

Fighting the parasite for control of his own body, Leon uses his last remaining strength to get Ashley to the lab in desperate hope that Luis's legacy can still save them.

Resident Evil 4 Remake: Chapter 16 Walkthrough

Resident Evil 4 Remake: Chapter 16 Walkthrough 1
Image: Push Square

Both Leon and Ashley have finally had the parasites taken out of their bodies, so it's time to leave the Island (and finish the game!) for good.

Escape from the Island

Exit Luis's Laboratory the same way you came in, then give Ashley a boost up to the ladder in the warehouse. Take the Velvet Blue and return to the main Sanctuary area, where you can drop down and make your way through the rubble. Grab the Iluminados Pendant before you climb up the other side, then follow the path through the cave, dealing with the Novistadors as you go. Take the Gold Ingot, then converse with the Merchant for one last time this playthrough. When you're ready, take the Elevator down to the final boss.

Defeat Saddler

In order to down Saddler for good, you'll need to first target the eyeballs that appear on his many limbs. Shoot each one enough to destroy it, then Saddler will be staggered, allowing you to get in close and stick a knife into its weak point. You'll need to repeat this process a number of times to defeat the boss.

Attacks to look out for include a stream of black liquid fired at you, which can knock off almost your entire health bar. It'll also leap into the air to stagger you and then deal damage. As the fight progresses, you'll need to destroy more eyeballs on its arms and legs, and Novistadors will become an annoying distraction. Saddler is also able to destroy parts of the arena as he leaps about, making navigation tougher.

After stabbing Saddler four or so times, he'll make one last stand. You can't go anywhere in this section, so simply shoot the giant, glowing sphere in the centre as much as possible until Ada throws you a Rocket Launcher. This kills Saddler for good.

Escape from the Island

After the cutscene, you'll have a two-minute timer to escape the Island. There's no combat left, so just make a run for it and grab the Clockwork Castellan until you reach the Water Scooter. Hop on board and avoid the debris and falling rock as you escape the Island for good. Once you spot daylight and reach the open air, you've now completed Resident Evil 4. Congratulations! Watch the credits and stick around for a few stingers. If you want to play through the game again, information on New Game+ can be found through the link.

Did you find our Chapter 16 walkthrough for Resident Evil 4 useful? Click through to our Resident Evil 4 Remake guide for more information and share any further tips in the comments below.