If you want to add its Platinum Trophy to your collection, it looks like you're either going to have to do multiple playthroughs or time your saves carefully so that you can return to certain spots and make different choices within the story. Two Trophies require you to save rivalling factions at a particular point in the plot, while other trinkets can be earned for a variety of endings.
The Trophy list confirms that you can start a relationship with at least four different people, both male and female, and earning a good reputation with different communities leads to rewards. Are you planning on purchasing GreedFall next week? Spend your skill points in the comments below.