That accolade belongs to another Activision title — Guitar Hero 3. According to NPD data (going back as far as 1995), the mainstream plastic instrument title is the highest-grossing game of "this generation". Of course, Black Ops is in second.
In fact, say what you will about Activision but they pretty much dominate the top ten alongside Nintendo. No less than five of the top-selling properties belong to the publisher. Of course, it might well be the highest-grossing game of the generation, but that wasn't enough to reverse the fortunes of the franchise. Activision killed the series earlier in the year.
- Guitar Hero 3: Legends of Rock
- Call of Duty: Black Ops
- Wii Fit
- Call of Duty: Modern Warfare 2
- Rock Band
- Wii Play (with Wii Remote)
- Guitar Hero: World Tour
- Wii Fit Plus
- Mario Kart (with wheel)
- Call of Duty 4: Modern Warfare