Animator David Lam's industry profile lists work on an "Unannounced Project" from Naughty Dog, starting in January 2010. Lam worked with Naughty Dog for eight months during the development of Uncharted 2: Among Thieves.
Y'know, we're absolutely ready for more Uncharted. It's probably going to be a couple of years until we get it. But it's alright to start getting excited, isn't it?