Naughty Dog's Uncharted 2: Among Thieves was the biggest winner, snatching awards for Best Graphics, Best PS3 Game, and the coveted Game Of The Year Award.
PushSquare's closet favourite, flower, also got a nod, winning the best Independant Game award.
God Of War III rounded out Sony's sweep, winning the Most Anticipated 2010 award.
Full list of winners after the jump.
Game of the Year: Uncharted 2: Among Thieves
Studio of the Year: Rocksteady Studios
Best Independent Game: Flower
Best Xbox 360 Game: Left 4 Dead 2
Best PS3 Game: Uncharted 2: Among Thieves
Best Wii Game: New Super Mario Bros. Wii
Best PC Game: Dragon Age: Origins
Best Handheld Game: Grand Theft Auto: Chinatown Wars
Best Shooter: Call of Duty: Modern Warfare 2
Best Fighting Game: Street Fighter IV
Best Action Adventure Game: Assassin's Creed II
Best RPG: Dragon Age: Origins
Best Multiplayer Game: Call of Duty: Modern Warfare 2
Best Individual Sports Game: UFC 2009 Undisputed
Best Team Sports Game: NHL 10
Best Driving Game: Forza Motorsport 3
Best Music Game: The Beatles: Rock Band
Best Soundtrack: DJ Hero
Best Original Score: Halo 3: ODST
Best Graphics: Uncharted 2: Among Thieves
Best Game Based On A Movie/TV Show: South Park Let's Go Tower Defense Play!
Best Performance By A Human Female: Megan Fox (Transformers: Revenge of the Fallen)
Best Performance By A Human Male: Hugh Jackman (X-Men Origins: Wolverine)
Best Cast: X-Men Origins: Wolverine
Best Voice: Jack Black (Brütal Legend) [Nolan North!?!? - Ed]
Best Downloadable Game: Shadow Complex
Best DLC: Grand Theft Auto IV: The Ballad of Gay Tony
Most Anticipated Game of 2010: God of War III